Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 118)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0721335	0.0998201	0.4778757
Weighted median	23	-0.0127917	0.0565130	0.8209300
Inverse variance weighted	23	-0.0286907	0.0390156	0.4621180
Simple mode	23	-0.0539256	0.1038902	0.6088989
Weighted mode	23	-0.0185338	0.0740556	0.8047022

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.40860	21	0.7462718
Inverse variance weighted	16.63217	22	0.7833228

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026678	0.0056423	0.6412162

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005204	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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