Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 117)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0569174	0.1085520	0.6055382
Weighted median	23	0.0044141	0.0546397	0.9356117
Inverse variance weighted	23	-0.0094964	0.0418867	0.8206451
Simple mode	23	0.0285382	0.0815385	0.7296696
Weighted mode	23	0.0171694	0.0624127	0.7858105

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.83421	21	0.2544162
Inverse variance weighted	25.35669	22	0.2803236

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040784	0.0061358	0.5134822

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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