Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 116)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0138624	0.0998214	0.8908743
Weighted median	23	-0.0035165	0.0517316	0.9458045
Inverse variance weighted	23	-0.0111538	0.0390159	0.7749721
Simple mode	23	-0.0521008	0.0845658	0.5441527
Weighted mode	23	-0.0049785	0.0611103	0.9358072

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	7.519026	21	0.9968700
Inverse variance weighted	7.519895	22	0.9982211

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001663	0.0056424	0.97676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002304	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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