Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 115)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0426569	0.1011799	0.6776051
Weighted median	23	0.0032673	0.0552641	0.9528556
Inverse variance weighted	23	0.0293353	0.0391834	0.4540587
Simple mode	23	-0.0152522	0.0916065	0.8692869
Weighted mode	23	-0.0057282	0.0645170	0.9300558

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.57566	21	0.4243055
Inverse variance weighted	22.18960	22	0.4486217

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004421	0.0057192	0.4481251

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006895	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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