Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 114)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0157010	0.1078616	0.8856524
Weighted median	23	0.0132854	0.0564443	0.8139205
Inverse variance weighted	23	0.0027898	0.0412059	0.9460216
Simple mode	23	0.0031488	0.0920628	0.9730236
Weighted mode	23	-0.0007012	0.0616706	0.9910303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.51963	21	0.2685677
Inverse variance weighted	24.53938	22	0.3196046

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007929	0.0060968	0.8977674

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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