Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 113)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1032569	0.1198381	0.3986199
Weighted median	23	0.0052874	0.0571572	0.9262952
Inverse variance weighted	23	-0.0522647	0.0478800	0.2750186
Simple mode	23	-0.0040706	0.0967140	0.9668076
Weighted mode	23	0.0081711	0.0613558	0.8952647

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.26728	21	0.0867471
Inverse variance weighted	33.13242	22	0.0600353

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095504	0.0067737	0.1732019

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010583	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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