Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 112)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0589510	0.1059554	0.5838349
Weighted median	23	0.0924391	0.0579435	0.1106381
Inverse variance weighted	23	0.0710201	0.0421374	0.0919032
Simple mode	23	0.0744145	0.1154037	0.5257119
Weighted mode	23	0.0593954	0.0765190	0.4458861

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.66077	21	0.3097840
Inverse variance weighted	25.66180	22	0.2664854

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079815	0.0059891	0.1969204

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000878	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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