Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 111)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0172607	0.0998201	0.8643713
Weighted median	23	0.0458912	0.0573208	0.4233613
Inverse variance weighted	23	0.0349719	0.0390156	0.3700623
Simple mode	23	0.0807298	0.0898515	0.3786582
Weighted mode	23	0.0651388	0.0783558	0.4147246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.30796	21	0.5018368
Inverse variance weighted	20.63114	22	0.5436232

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032076	0.0056423	0.5757315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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