Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 110)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2711444	0.1022831	0.0149467
Weighted median	23	0.0732675	0.0579066	0.2057749
Inverse variance weighted	23	0.0523102	0.0437962	0.2323216
Simple mode	23	-0.1152998	0.1039356	0.2792637
Weighted mode	23	0.0935294	0.0688190	0.1878966

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.04935	21	0.3966708
Inverse variance weighted	27.72215	22	0.1850730

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0134386	0.0057815	0.0302149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008945	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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