Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 11)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1161487	0.0998199	0.2576440
Weighted median	23	-0.0150713	0.0576218	0.7936640
Inverse variance weighted	23	0.0295344	0.0390156	0.4490566
Simple mode	23	-0.0597968	0.1018766	0.5632107
Weighted mode	23	-0.0567436	0.0773152	0.4707441

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.5679	21	0.6128372
Inverse variance weighted	21.0820	22	0.5156751

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0089464	0.0056423	0.1277759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006562	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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