Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 109)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1588884	0.1194423	0.1977024
Weighted median	23	0.0142383	0.0666680	0.8308828
Inverse variance weighted	23	-0.0081404	0.0480530	0.8654786
Simple mode	23	-0.2221097	0.1430065	0.1346570
Weighted mode	23	0.1025942	0.1063499	0.3451873

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.06893	21	0.0906115
Inverse variance weighted	33.37387	22	0.0568048

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102573	0.0067515	0.14361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8