Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 108)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0590234	0.0998203	0.5606330
Weighted median	23	-0.0555137	0.0542458	0.3061316
Inverse variance weighted	23	-0.0196474	0.0390155	0.6145575
Simple mode	23	-0.0814787	0.0867795	0.3579683
Weighted mode	23	-0.0731337	0.0697705	0.3059247

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	7.771808	21	0.9960379
Inverse variance weighted	8.504951	22	0.9955472

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048312	0.0056424	0.4015314

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002654	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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