Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 107)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0935774	0.1087431	0.3992121
Weighted median	23	-0.0193298	0.0569203	0.7341627
Inverse variance weighted	23	-0.0040589	0.0423099	0.9235747
Simple mode	23	0.0449694	0.0876699	0.6131061
Weighted mode	23	0.0119791	0.0612317	0.8466908

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.92271	21	0.2505273
Inverse variance weighted	25.87200	22	0.2572184

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054974	0.0061467	0.3812667

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007843	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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