Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 106)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0596697	0.1341637	0.6610485
Weighted median	23	-0.0320671	0.0586869	0.5847841
Inverse variance weighted	23	-0.0531440	0.0512367	0.2996305
Simple mode	23	-0.0348646	0.1085892	0.7511887
Weighted mode	23	-0.0348646	0.0859607	0.6889634

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.93673	21	0.0131103
Inverse variance weighted	37.94178	22	0.0185993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004007	0.0075836	0.9583564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012059	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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