Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 105)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1178844	0.0998201	0.2508183
Weighted median	23	0.0152802	0.0544582	0.7790274
Inverse variance weighted	23	0.0066929	0.0390157	0.8637965
Simple mode	23	0.0107322	0.0890829	0.9052011
Weighted mode	23	0.0529646	0.0652336	0.4255352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.56056	21	0.8443389
Inverse variance weighted	16.02512	22	0.8146370

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068283	0.0056423	0.2396524

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004865	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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