Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 104)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0827543	0.1116296	0.4667038
Weighted median	23	0.0784011	0.0596786	0.1889398
Inverse variance weighted	23	0.0692203	0.0426456	0.1045572
Simple mode	23	0.1263403	0.1170563	0.2921398
Weighted mode	23	0.1421645	0.0839114	0.1043349

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.2633	21	0.1965867
Inverse variance weighted	26.2850	22	0.2396468

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008311	0.0063099	0.896461

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8