Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 103)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0695547	0.1001279	0.4948838
Weighted median	23	0.0838597	0.0628406	0.1820458
Inverse variance weighted	23	0.0524268	0.0390151	0.1790264
Simple mode	23	0.1401102	0.1146464	0.2346002
Weighted mode	23	0.1460845	0.0873685	0.1086787

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.13060	21	0.4509932
Inverse variance weighted	21.16536	22	0.5105397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010518	0.0056597	0.8543502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8