Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 102)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0989206	0.0998210	0.3329772
Weighted median	23	0.0207042	0.0566944	0.7149703
Inverse variance weighted	23	0.0318982	0.0390157	0.4136006
Simple mode	23	-0.0529018	0.0914120	0.5686576
Weighted mode	23	-0.0098058	0.0641879	0.8799745

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.62107	21	0.9492875
Inverse variance weighted	13.64826	22	0.9134916

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080336	0.0056424	0.1691953

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004338	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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