Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 101)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2641007	0.0998183	0.0151158
Weighted median	23	0.0776758	0.0573904	0.1759074
Inverse variance weighted	23	0.0581426	0.0390152	0.1361574
Simple mode	23	0.0975310	0.0970709	0.3259459
Weighted mode	23	0.0975310	0.0697976	0.1762458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.86757	21	0.9131915
Inverse variance weighted	17.89259	22	0.7123370

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012648	0.0056423	0.0359135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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