Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 100)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0814121	0.0998203	0.4238911
Weighted median	23	-0.0585008	0.0552091	0.2893171
Inverse variance weighted	23	0.0030659	0.0390156	0.9373646
Simple mode	23	0.1662460	0.1030059	0.1207922
Weighted mode	23	-0.0744412	0.0718263	0.3112713

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.31813	21	0.8066571
Inverse variance weighted	16.16350	22	0.8076889

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051878	0.0056423	0.3683056

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00049	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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