Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 10)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0174924	0.1183222	0.8838818
Weighted median	23	-0.0115612	0.0598974	0.8469465
Inverse variance weighted	23	0.0188520	0.0451839	0.6765109
Simple mode	23	-0.0439296	0.1237786	0.7260405
Weighted mode	23	-0.0470712	0.0857534	0.5885930

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.50704	21	0.1023508
Inverse variance weighted	29.50726	22	0.1309404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
8.35e-05	0.0066882	0.9901572

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009012	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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