Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 1)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0071568	0.1162504	0.9514926
Weighted median	23	0.0269995	0.0581191	0.6422501
Inverse variance weighted	23	-0.0245771	0.0444214	0.5800774
Simple mode	23	-0.0175005	0.0917680	0.8505063
Weighted mode	23	0.0330870	0.0634376	0.6071833

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.48303	21	0.1269762
Inverse variance weighted	28.51898	22	0.1591131

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010698	0.006571	0.8722301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008761	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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