Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 999)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0486858	0.1100599	0.6627532
Weighted median	23	0.0386129	0.0590034	0.5128417
Inverse variance weighted	23	0.0280241	0.0425986	0.5106245
Simple mode	23	0.1338108	0.1184133	0.2706331
Weighted mode	23	-0.0120225	0.0777457	0.8785159

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.52941	21	0.2249634
Inverse variance weighted	26.22646	22	0.2420861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047108	0.0062211	0.4573313

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008104	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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