Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 998)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0363585 0.1049002 0.7323401
Weighted median 23 0.0303520 0.0590758 0.6074054
Inverse variance weighted 23 -0.0154723 0.0403327 0.7012616
Simple mode 23 -0.0186881 0.1174593 0.8750392
Weighted mode 23 0.0225497 0.0921900 0.8090327

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.19254 21 0.3337991
Inverse variance weighted 23.51078 22 0.3733851

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0031829 0.0059295 0.5970481

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007172 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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