Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 997)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0536468	0.0998209	0.5966200
Weighted median	23	-0.0063414	0.0556652	0.9093007
Inverse variance weighted	23	-0.0082087	0.0390158	0.8333589
Simple mode	23	0.0357215	0.0879767	0.6886399
Weighted mode	23	0.0147116	0.0644751	0.8216182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.99972	21	0.8696114
Inverse variance weighted	14.45294	22	0.8846273

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037985	0.0056424	0.50815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004393	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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