Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 996)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1386336	0.1166317	0.2478483
Weighted median	23	-0.0135781	0.0566729	0.8106506
Inverse variance weighted	23	-0.0004953	0.0462610	0.9914580
Simple mode	23	0.0540850	0.1072070	0.6189319
Weighted mode	23	-0.0335361	0.0668671	0.6209774

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.66947	21	0.1221656
Inverse variance weighted	30.92992	22	0.0975584

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008483	0.0065926	0.2121828

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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