Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 995)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1748827	0.0998202	0.0943694
Weighted median	23	0.0989455	0.0545748	0.0698278
Inverse variance weighted	23	0.0261126	0.0399637	0.5134930
Simple mode	23	0.1298265	0.0929126	0.1762584
Weighted mode	23	0.1155758	0.0602736	0.0682471

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.46078	21	0.4922663
Inverse variance weighted	23.08254	22	0.3970816

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091359	0.0056423	0.1203292

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000713	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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