Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 994)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2204667	0.0998205	0.0384505
Weighted median	23	0.0647004	0.0561133	0.2488979
Inverse variance weighted	23	0.0375595	0.0407542	0.3567317
Simple mode	23	0.0544936	0.0907335	0.5542509
Weighted mode	23	0.0776792	0.0624380	0.2265550

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.04151	21	0.5186333
Inverse variance weighted	24.00448	22	0.3469946

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0112323	0.0056423	0.0596837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007555	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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