Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 993)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1092939	0.1052587	0.3109222
Weighted median	23	-0.0223771	0.0572960	0.6961280
Inverse variance weighted	23	-0.0232095	0.0409438	0.5708077
Simple mode	23	0.0733357	0.0954041	0.4502541
Weighted mode	23	-0.0013755	0.0604719	0.9820579

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.35039	21	0.3255844
Inverse variance weighted	24.22822	22	0.3353815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052864	0.0059497	0.3843274

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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