Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 992)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0785032	0.0998204	0.4403925
Weighted median	23	0.0348690	0.0529188	0.5099502
Inverse variance weighted	23	0.0497262	0.0390156	0.2024787
Simple mode	23	-0.0446510	0.0942529	0.6403556
Weighted mode	23	0.0151215	0.0632432	0.8132405

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.39200	21	0.7472376
Inverse variance weighted	16.49009	22	0.7908407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017672	0.0056423	0.7572167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005489	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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