Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 991)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0459126	0.1132270	0.6892179
Weighted median	23	0.0229300	0.0569099	0.6870088
Inverse variance weighted	23	0.0215157	0.0432946	0.6192164
Simple mode	23	-0.0300713	0.0952784	0.7552692
Weighted mode	23	-0.0029301	0.0651649	0.9645415

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.01973	21	0.1702010
Inverse variance weighted	27.09024	22	0.2078192

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014982	0.0064001	0.8171822

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8