Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 990)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1484305	0.0998194	0.1518786
Weighted median	23	0.1222348	0.0576345	0.0339333
Inverse variance weighted	23	0.0717476	0.0390154	0.0659217
Simple mode	23	0.1863072	0.1047839	0.0892281
Weighted mode	23	0.1258622	0.0680134	0.0777096

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.35454	21	0.7494119
Inverse variance weighted	17.05111	22	0.7605347

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047091	0.0056423	0.4133319

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006192	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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