Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 99)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0387585	0.1169671	0.7436549
Weighted median	23	-0.0525874	0.0574330	0.3598609
Inverse variance weighted	23	-0.0269967	0.0446790	0.5456858
Simple mode	23	-0.1375347	0.0971329	0.1707945
Weighted mode	23	-0.0476137	0.0696003	0.5010538

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.83465	21	0.1180282
Inverse variance weighted	28.85104	22	0.1491632

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007223	0.0066115	0.9140441

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008887	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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