Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 989)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0274775	0.0998203	0.7857997
Weighted median	23	0.0322826	0.0557547	0.5625825
Inverse variance weighted	23	0.0073304	0.0390157	0.8509688
Simple mode	23	0.0295725	0.1120907	0.7943693
Weighted mode	23	0.0512914	0.0755114	0.5040618

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.54764	21	0.7381358
Inverse variance weighted	16.69116	22	0.7801687

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021375	0.0056423	0.7086088

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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