Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 988)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0142048	0.1058938	0.8945672
Weighted median	23	-0.0342580	0.0596559	0.5657924
Inverse variance weighted	23	-0.0066150	0.0404436	0.8700766
Simple mode	23	-0.1339882	0.1000355	0.1941125
Weighted mode	23	-0.0783131	0.0777774	0.3249356

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.63328	21	0.3111642
Inverse variance weighted	23.64010	22	0.3663732

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004661	0.0059856	0.9386698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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