Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 987)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0926886	0.0998199	0.3636690
Weighted median	23	-0.0542774	0.0548372	0.3222756
Inverse variance weighted	23	-0.0412123	0.0390156	0.2908299
Simple mode	23	-0.0494854	0.0937509	0.6028944
Weighted mode	23	-0.0716509	0.0717486	0.3288282

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.50538	21	0.8469284
Inverse variance weighted	14.81927	22	0.8698764

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031612	0.0056423	0.5812301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004829	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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