Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 986)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1259366	0.1133041	0.2789205
Weighted median	23	0.0782807	0.0584080	0.1801675
Inverse variance weighted	23	0.0514796	0.0437896	0.2397493
Simple mode	23	0.0994069	0.0861050	0.2606887
Weighted mode	23	0.0621383	0.0660038	0.3567055

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.05681	21	0.1689807
Inverse variance weighted	27.71352	22	0.1853706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045724	0.0064045	0.4831274

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008926	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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