Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 985)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0415434	0.1107388	0.7113132
Weighted median	23	-0.0162816	0.0554732	0.7691370
Inverse variance weighted	23	-0.0469019	0.0422907	0.2674149
Simple mode	23	-0.0636574	0.1007189	0.5338809
Weighted mode	23	-0.0029306	0.0613170	0.9623109

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.84506	21	0.2124186
Inverse variance weighted	25.84846	22	0.2582452

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003291	0.0062595	0.9585709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008271	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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