Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 984)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0171165	0.0998213	0.8654948
Weighted median	23	0.0303674	0.0543782	0.5765381
Inverse variance weighted	23	0.0292907	0.0390159	0.4528109
Simple mode	23	0.0868125	0.0810121	0.2955154
Weighted mode	23	0.0351413	0.0577749	0.5492541

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.441154	21	0.9852965
Inverse variance weighted	9.458711	22	0.9905842

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007476	0.0056424	0.8958504

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003037	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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