Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 983)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1352639	0.0998204	0.1897928
Weighted median	23	0.0219695	0.0575021	0.7024143
Inverse variance weighted	23	0.0036609	0.0390154	0.9252426
Simple mode	23	-0.0503876	0.1072022	0.6429638
Weighted mode	23	0.0269432	0.0725961	0.7140848

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.39605	21	0.6238216
Inverse variance weighted	20.44764	22	0.5550605

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080817	0.0056423	0.1667655

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8