Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 982)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1637569	0.0998199	0.1157904
Weighted median	23	-0.0732536	0.0565690	0.1953405
Inverse variance weighted	23	-0.0182241	0.0390155	0.6404292
Simple mode	23	-0.0600766	0.0877779	0.5008595
Weighted mode	23	-0.0658997	0.0668051	0.3346393

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.13030	21	0.8163575
Inverse variance weighted	17.63922	22	0.7271520

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0089372	0.0056423	0.1281482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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