Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 981)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0318905	0.0998675	0.7526327
Weighted median	23	-0.0179948	0.0576342	0.7548700
Inverse variance weighted	23	-0.0480310	0.0390155	0.2182949
Simple mode	23	-0.0759279	0.0900661	0.4082875
Weighted mode	23	-0.0111505	0.0710294	0.8766896

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.01978	21	0.4577365
Inverse variance weighted	21.77642	22	0.4732998

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004908	0.005645	0.3944372

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007058	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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