Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 980)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0859496	0.1137761	0.4583825
Weighted median	23	-0.0224195	0.0578672	0.6984371
Inverse variance weighted	23	0.0011357	0.0441575	0.9794816
Simple mode	23	0.0552191	0.0985780	0.5810327
Weighted mode	23	-0.0334732	0.0656265	0.6150908

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.28286	21	0.1616855
Inverse variance weighted	28.18124	22	0.1697524

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053479	0.0064312	0.4150138

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000854	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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