Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 98)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0573703	0.1012436	0.5769544
Weighted median	23	0.0102181	0.0535325	0.8486223
Inverse variance weighted	23	-0.0046743	0.0390678	0.9047640
Simple mode	23	0.0242468	0.0879838	0.7854403
Weighted mode	23	0.0323111	0.0614352	0.6041929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.60295	21	0.4226909
Inverse variance weighted	22.05895	22	0.4563746

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038101	0.0057228	0.5127944

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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