Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 979)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0505376	0.1020468	0.6255732
Weighted median	23	0.0617441	0.0587165	0.2930000
Inverse variance weighted	23	-0.0113165	0.0393688	0.7737700
Simple mode	23	0.1081309	0.1047354	0.3130920
Weighted mode	23	0.0723216	0.0650586	0.2782950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.94713	21	0.4025623
Inverse variance weighted	22.40033	22	0.4362224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037984	0.0057682	0.5173606

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006813	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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