Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 977)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0642220	0.1088707	0.5615570
Weighted median	23	0.0270085	0.0607588	0.6566668
Inverse variance weighted	23	0.0291261	0.0416960	0.4848427
Simple mode	23	0.1041662	0.0965921	0.2925321
Weighted mode	23	0.0255276	0.0758585	0.7396710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.98132	21	0.2479742
Inverse variance weighted	25.12723	22	0.2910293

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021552	0.0061539	0.7296598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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