Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 976)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1127882	0.0998206	0.2712561
Weighted median	23	-0.0080319	0.0547289	0.8833231
Inverse variance weighted	23	0.0053981	0.0390157	0.8899575
Simple mode	23	-0.0022267	0.0833682	0.9789326
Weighted mode	23	0.0040993	0.0605153	0.9466050

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.24358	21	0.7558129
Inverse variance weighted	17.60969	22	0.7288628

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065948	0.0056423	0.2555785

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005342	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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