Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 975)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0305955	0.1329532	0.8202238
Weighted median	23	-0.0418864	0.0600083	0.4851714
Inverse variance weighted	23	-0.0192053	0.0507811	0.7052845
Simple mode	23	-0.1136664	0.1059802	0.2951088
Weighted mode	23	-0.0540365	0.0636595	0.4051149

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.25457	21	0.0157358
Inverse variance weighted	37.26994	22	0.0220916

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006995	0.0075151	0.9267266

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011367	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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