Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 974)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1210492	0.1020286	0.2487045
Weighted median	23	-0.0403281	0.0579752	0.4866734
Inverse variance weighted	23	-0.0379118	0.0396821	0.3393816
Simple mode	23	-0.0480424	0.0980455	0.6289838
Weighted mode	23	-0.0506642	0.0679331	0.4636859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.93951	21	0.4030028
Inverse variance weighted	22.75827	22	0.4154852

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051055	0.0057672	0.3860379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007182	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8