Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 973)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1419126	0.1038018	0.1860357
Weighted median	23	-0.0584911	0.0560460	0.2966577
Inverse variance weighted	23	-0.0523533	0.0404600	0.1956822
Simple mode	23	-0.0469293	0.0975744	0.6352946
Weighted mode	23	-0.0603393	0.0664163	0.3734587

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.70909	21	0.3596832
Inverse variance weighted	23.65924	22	0.3653416

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054998	0.0058674	0.3592305

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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